ACE-2 (Mammalian, C-Avi-6His)-20ug

[Packing] 20ug

[DESCRIPTION]

Biotinylated Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian
expression system and the target gene encoding Gln18-Ser740 is expressed with a Avi, 6His tag at the C-
terminus.

Accession:Q9BYF1

Known as:Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-
Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2

[QUALITY CONTROL]

Mol Mass:86.2kDa       AP Mol Mass:110-140kDa, reducing conditions.

Purity:Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin:Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.

Biotin:Protein Ratio    The biotin to protein ratio is 0.5-1 as determined by the HABA assay.

[FORMULATION]

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl 2 , 10% Glycerol, pH 7.4.

[SHIPPING]

The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.

[STORAGE]

Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

[BACKGROUND]

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease
of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II
as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin
1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high
expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril
and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role
in regulating the heart function.

[SDS-PAGE]

FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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