KEL BIOTECH Tetanus toxin recombinant proteinCRM197

Product introduction:

The CRM197 protein is a variant of the diphtheria toxin (DT) protein without toxicity. This loses enzymatic activity and toxicity due to the amino acid substitution G53E in the DT protein, but it still retains immunogenicity. CRM197 has a range of applications, such as in bacterial polysaccharide conjugate vaccines, CRM197 is often used as a protein carrier to enhance immunogenicity and immunological memory. protein is also used as an antigen component of vaccines, which is applied in the research and development of recombinant diphtheria vaccines. In addition, CRM19 is applied in the development of anti-tumor drugs due to its function of binding specific receptors.

The CRM197 freeze-dried powder of KEL Biotech been optimized for a long time, and it can provide a specification that meets the requirements of any clinical research or commercial production.

Avoids slow, complex and costly production in pathogenic microorganisms

• KEL™ CRM197 is of higher purity compared to that with other expression systems
• Research grade and cGMP-grade recombinant KEL™ CRM197 carrier protein are available (3)
• The product and consistency is maintained from research grade (mg scale) to cGMP grade (kg scale)
• Accelerates the development of vaccines entering the clinic, being a cost- source of key materials for vaccine development and commercialization.

Note:

• Recombinant CRM197 (bulk) product is manufactured in accordance with the current cGMPs for the production of bichnological/biological products and ICH Q7 and ICH Q11 (as applicable) guidance documents, with recombinant CRM197 (bulk) as starting material of active substance for further manufacture of suitable drug substance and/or drug product by the ultimate user.

Dosage of KEL™ CRM197:

1. After receiving the KEL™ CRM197 freeze-dried powder, please it at -20°C.
2. Before use, reconstitute the freeze-dried KEL™ CRM197 with sterile DI water to a concentration of4 mg/mL.
3. The prepared recombinant KEL™ CRM197 should be stored at 2-8°C.

KEL™ CRM197 Product Information: