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S1 Protein (Mammalian,C-Fc)-1mg

S1 Protein (Mammalian,C-Fc)-1mg

  • Model: NDRA37
  • Price:

    $4,000.00

    Qty:
    Note: Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.

    Product Description

    [Packing] 1mg

    [DESCRIPTION]

    Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed with a Fc tag at the C-terminus.

    Accession:QHD43416.1

    Known as:S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein

    [QUALITY CONTROL]

    Mol Mass:102.2kDa      AP Mol Mass:130-140kDa, reducing conditions

    Purity:Greater than 90% as determined by reducing SDS-PAGE.

    [FORMULATION]

    Supplied as a 0.2 μM filtered solution of PBS, pH 7.4

    [SHIPPING]

    The product is shipped on dry ice pack.
    Upon receipt, store it immediately at the temperature listed below.

    [STORAGE]

    Reconstituted protein solution should be stored at ≤ -20°C.

    [PURIFICATION]

    Affinity purification chromatography

    [IMMUNOREACTIVITY]N.A.

    [APPLICATION]Immunogen, calibrator or standard.

    [BACKGROUND]

    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in
    multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

     

     

    FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
    Aicon Biotech,Inc

    Features

    • Model: NDRA37
    • 999 Units in Stock

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    Shipping info

    $50.00 to United States

    Contact us to order

    +1(206)6369998 +1(503)2681752


    This product was added to our catalog on Friday 20 March, 2020.