[Packing] 1mg
[DESCRIPTION]
Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system
and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.
Accession:Q9BYF1
Known as:Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting
Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
[QUALITY CONTROL]
Mol Mass:110.5kDa AP Mol Mass:110-140kDa, reducing conditions.
Purity:Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin:Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
[FORMULATION]
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
[SHIPPING]
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
[STORAGE]
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
[BACKGROUND]
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of
the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a
carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7.
ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high
expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and
lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in
regulating the heart function.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
Aicon Biotech,Inc
